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Partner Presentation

Professor Ole Nørregaard Jensen:

Professor Ole Nørregaard Jensen University of Southern Denmark

 

Professor Ole Nørregaard Jensen provides a state-of-the-art proteomics platform for this NCoE project. His research is focused on the development of highly sensitive mass spectrometry based technology for protein identification, characterization and quantitation, and proteome wide analysis of post-translational modifications (PTMs). Several sensitive and specific affinity-enrichment methods for quantitative phosphoproteomics studies of cellular signal transduction were developed in the Jensen group. The Protein Research group recently embarked on the proteomic analysis human muscle mitochondria and human beta-cells in the context of diabetes and the metabolic syndrome.

Ole N. Jensen participates in the EU Marie-Curie Research Training Network ’DNA Enzymes’ (9 partners) and is part of the Danish National Research Foundations Center-of-excellence in Epigenetics. The Protein Research Group participates in several other EU projects and a HFSP project in the areas of aging and neurobiology.

Role in NCoE MitoHealth:

• Investigation of the effects on lipids on the mitochondrial proteome and on phosphorylation mediated signaling in mitochondria.
• Providing a proteomics platform for partner projects within the NCoE.
• Education and training of researchers in biological mass spectrometry and related proteomics technologies

Technologies :

Mass spectrometry platforms, including several MALDI MS/MS and ESI MS/MS instruments. The newest acquisitions include a Thermo LTQ-Orbitrap MS/MS instrument, a Waters Synapt IMS-MS/MS instrument and an Agilent iontrap ETD MS/MS system. In addition, several QTOF and TOF-TOF instruments are available. Chromatography and electrophoresis equipment for protein and peptide separations is used in conjunction with mass spectrometry for detailed characterization of proteins. Hydrogen-deuterium exchange mass spectrometry (HX-MS) and surface plasmon resonance analysis (Biacore) is applied to the study of protein-protein and protein-ligand interactions. Laser microcapture dissection equipment was recently installed for preparation of tissue samples for proteomic analysis. Bioinformatics tools are developed and applied to the study and interpretation of complex proteomics datasets.

Links:

Protein Research Group: www.protein.sdu.dk

Centre for Epigenetics: www.epigenetics.dk

DNA-Enzymes: https://genesilico.pl/DNAenzymes/