Publications and Articles
Publications MitoHealth
Z.-J. Chen, R. Pudas, S. Sharma, O.S Smart, A.H. Juffer, J.K Hiltunen, R.K. Wierenga, &
A.M. Haapalainen, (2008) Crystal structure of 2-enoyl thiester reductase of human FAS II:
new insight into substrate binding and catalysis. J. Mol. Biol, 379, 830-844
K.J. Autio, A.J. Kastaniotis, H. Pospiech,. I.J. Miinalainen, M.S. Schonauer, C.L.
Dieckmannn & J.K. Hiltunen (2008) An ancient genetic link between vertebrate
mitochondrial fatty acid synthesis and RNA processing. FASEB J, 22, 569-578
Z.-J. Chen, A. J. Kastaniotis, I. J. Miinalainen, V. Rajaram, R. K. Wierenga, & J. K.
Hiltunen (2009) Heteromeric (17β-HSD8)2(CBR4)2 is the ketoacyl reductase (KAR) of
mitochondrial FAS in human. FASEB J, 23, 3682-3691
Z.-J. Chen, H. Leskinen, E. Liimatta, R.T. Sormunen, I. J. Miinalainen, I. E. Hassinen, & J.
K. Hiltunen (2009) Overexpression of 2-enoyl thioester reductase of mitochondrial FAS II in
myocardial leads to cardiac dysfunction in mouse. Plos One, 4, e5589
I.J. Miinalainen, W. Schmitz,. R. Soininen, K.J. Autio, A. Huotari, E. Ver Loren van
Themaat, M. Baes, K.-H. Herzig,. E. Conzelmann & J.K. Hiltunen (2009) Mitochondrial 2,4-dienoyl-CoA reductase-deficiency in mice results in severe hypoglycaemia with stress
intolerance and unimpaired ketogenesis. Plos Genetics, 5, e1000543
M.S. Manger, E. Strand, M. Ebbing, J.E. Nordrehaug, D.W. Nilsen, H. Refsum, C. Drevon,
G.S. Tell & O. Nygård. Dietary intake of long chain n-3 fatty acids and cardiovascular events
in patients with coronary artery disease. Submitted to Am. J. Clin. Nutr.
T. Hausken, R. K. Berge, A. Polder, J. Utne Skaare, M.Haugen, H. M. Meltzer, R. M. Nilsen, O. Nygård, A. K.L. Haldorsen & J. Skorve. Consumption of farmed salmon did not
increase the levels of persistent organic pollutants (POP) in patients with metabolic disorders.
Submitted to Food Additives and Contaminants.
H. Schartum-Hansen, E.R. Pedersen, P.M. Ueland, M. Ebbing, Ø. Bleie, J.E. Nordrehaug &
O. Nygaard Betaine excretion in urine is associated with components of the metabolic
syndrome and microalbuminuria. Submitted.
R. de Moraes, R.H. Valente, I.R. León, M.R.O. Trugilho, A.C.L. Nóbrega, J. Perales & E.
Tibiriçá. (2008) Chronic dynamic exercise increases apolipoprotein a-i expression in rabbit
renal cortex as determined by proteomic technology. British Journal of Sport Medicine;
42(5):386-8.
K. Zhang, K. Wrzesinski, S. J. Fey, P. Mose Larsen, X. Zhang, P. Roepstorff. (2008)
Assessing CMT Cell Line Stability by Two Dimensional Polyacrylamide Gel Electrophoresis
and Mass Spectrometry Based Proteome Analysi, J.Proteomics. 21; 71(2):160-167.
S.-J. Reilly, V. Tillander, R. Ofman, S.E.H. Alexson & M.C. Hunt (2008) The Nudix
hydrolase 7 is an acyl-CoA diphosphatase involved in regulating peroxisomal coenzyme A
homeostasis. J. Biochem. 144:655-663.
O.A. Gudbrandsen, H. Wergedahl, B. Liaset, M. Espe, S. Mørk & R.K. Berge (2008) Dietary
single cell protein reduces fatty liver in obese Zucker rats. Br. J. Nutr. 100.776-785
M. S. Schonauer, A.J. Kastaniotis, J.K. Hiltunen & Dieckmann, C. L. (2008) Intersection
of RNA Processing and the Type II Fatty Acid Synthesis Pathway in Yeast Mitochondria.
Mol. Cell. Biol. 28, 6646-6657
K.J. Autio, J.L Guler, A.J. Kastaniotis, P.T. Englund & J.K. Hiltunen (2008) 3-
Hydroxyacyl-ACP dehydratase of mitochondrial fatty acid synthesis in Trypanosoma brucei.
FEBS Lett, 582, 729-733
J.K. Hiltunen, Z. Chen, A.M. Haapalainen, R.K. Wierenga, & A.J. Kastaniotis (2009)
Mitochondrial fatty acid synthesis –an adopted set of enzymes making a pathway of major
importance for cellular metabolism. Prog. Lipid Res. doi:10.1016/j.plipres.2009.08.001
J.K. Hiltunen, M, Schonauer, K. J. Autio, T.M. Mittelmeier, A J. Kastaniotis & C. L.
Dieckmann, (2009) Mitochondrial FAS type II – more than just fatty acids. J. Biol. Chem,
284, 9011-9015
R.G. Boot, M.J. van Breemen, W. Wegdam, R.R. Sprenger, S. de Jong, D. Speijer, C.E.
Hollak, L. van Dussen, H.C., Hoefsloot A.K. Smilde, C.G. de Koster, J.P. Vissers & J.M.
Aerts (2009) ‘Gaucher disease: a model disorder for biomarker discovery’ Expert Rev.
Proteomics 6, 411-419
S. Pozzi, M. Børgesen, Satrajit Sinha, S. Mandrup & R. Mantovani (2009) Peroxisome
proliferator activated receptor alpha is a functional target of p63 in adult human keratinocytes.
J. Invest. Dermatology, 129, 2376-2385
A.J. Wensaas, A.C. Rustan, M. Just, R.K. Berge, C.A. Drevon & M. Gaster (2009) Fatty
acid incubation of myotubes from humans with type 2 diabetes leads to enhanced release of
beta-oxidation products because of impaired fatty acid oxidation: effects of
tetradecylthioacetic acid and eicosapentaenoic acid. Diabetes. 58,527-535
H. Wergedahl, O.A. Gudbrandsen, T.H. Røst & R.K. Berge (2009) Combination of fish oil
and fish protein hydrolysate reduces the plasma cholesterol level with a concurrent increase in
hepatic cholesterol level in high-fat-fed Wistar rats. Nutrition 25, 98-104
K. Ravnskjaer, F. Frigerio*, M. Børgesen*, T. Nielsen, P. Maechler & S. Mandrup. PPARδ
is a fatty acid sensor, which activates mitochondrial oxidation and protects insulin secreting
cells against lipotoxicity. J. Lipid Res., in press. (* equal contribution)
T. Lundåsen, E.-M. Andersson, M. Snaith, H. Lindmark, S. Schreyer, A-M. Östlund-
Lindqvist, B. Angelin & M. Rudling. Interruption of bile acid circulation improves
triglyceride metabolism and normalizes elevated plasma glucose levels. Manuscript
submitted.
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